The Faculty of Medicine, Duy Tan University, Da Nang, Vietnam.
University of Medicine and Pharmacy, Hue University, Hue, Vietnam.
PLoS One. 2024 Oct 24;19(10):e0305799. doi: 10.1371/journal.pone.0305799. eCollection 2024.
Diabetes is one of the leading causes of noncommunicable diseases worldwide. It is known to induce cardiovascular remodeling, which can result in a variety of complications, including a considerable increase in aortic stiffness. While studies in Western populations have explored these effects, data on Asians, mainly Vietnamese, are limited. This study aimed to assess aortic elasticity in type 2 diabetes mellitus (T2DM) patients compared to healthy individuals.
This quantitative, cross-sectional study compared aortic elasticity indices between individuals with T2DM and healthy controls in Vietnam. Aortic elasticity indices were assessed for all participants using M-mode echocardiography.
A comparison between the healthy and T2DM groups revealed substantial differences in aortic elasticity indices. The aortic stiffness index (ASI) was significantly greater in the T2DM group than in the control group, with median values of 6.10 (3.64-12.47) and 3.79 (2.40-8.50), respectively (p = 0.003). Aortic strain (AS) was substantially lower in the T2DM group than in the control group, with median values of 8.21% (4.24-13.07) and 10.66% (6.01-18.23), respectively (p = 0.039). Furthermore, the median aortic compliance (AC, 10-2mm/mmHg) and aortic distensibility (AD, 10-3mmHg-1) in individuals with T2DM were 4.07 (2.28-7.44) and 3.08 (1.57-5.26), respectively, lower than those in the control group, with median values of 6.40 (3.08-10.75) and 5.33 (2.80-9.79). A longer diabetes duration was linked to a greater ASI (r = 0.43, p < 0.05), while the AS decreased (r = -0.37, p < 0.05).
Substantial variations in aorta elasticity indices were found in patients with T2DM using M-mode echocardiography. These differences highlight the impact of T2DM on vascular health. More research is needed to investigate the consequences of these discrepancies and their significance for clinical purposes.
糖尿病是全球导致非传染性疾病的主要原因之一。已知它会引起心血管重构，从而导致多种并发症，包括主动脉僵硬度的显著增加。虽然西方人群的研究已经探讨了这些影响，但关于亚洲人（主要是越南人）的数据有限。本研究旨在评估 2 型糖尿病（T2DM）患者与健康个体的主动脉弹性。
这是一项在越南进行的定量、横断面研究，比较了 T2DM 患者和健康对照者的主动脉弹性指数。使用 M 型超声心动图评估所有参与者的主动脉弹性指数。
健康组和 T2DM 组之间的比较显示，主动脉弹性指数存在显著差异。T2DM 组的主动脉僵硬度指数（ASI）明显高于对照组，中位数分别为 6.10（3.64-12.47）和 3.79（2.40-8.50）（p = 0.003）。T2DM 组的主动脉应变（AS）明显低于对照组，中位数分别为 8.21%（4.24-13.07）和 10.66%（6.01-18.23）（p = 0.039）。此外，T2DM 患者的主动脉顺应性（AC，10-2mm/mmHg）和主动脉可扩张性（AD，10-3mmHg-1）的中位数分别为 4.07（2.28-7.44）和 3.08（1.57-5.26），均低于对照组的 6.40（3.08-10.75）和 5.33（2.80-9.79）。糖尿病病程较长与 ASI 增加相关（r = 0.43，p < 0.05），而 AS 降低（r = -0.37，p < 0.05）。
使用 M 型超声心动图发现 T2DM 患者的主动脉弹性指数存在显著差异。这些差异突出了 T2DM 对血管健康的影响。需要进一步研究这些差异的后果及其对临床的意义。
