Thomas Mark, Weekes Andrew J, Thomas Merlin C
Department of Nephrology, Royal Perth Hospital, Box X 2213, Perth, Australia.
BMC Public Health. 2007 Oct 25;7:303. doi: 10.1186/1471-2458-7-303.
Indigenous Australians have high rates of diabetes and its complications. This study examines ethnic differences in the management of patients with type 2 diabetes in Australian primary care.
Diabetes management and outcomes in Indigenous patients enrolled in the NEFRON study (n = 144) was systematically compared with that in non-Indigenous patients presenting consecutively to the same practitioner (n = 449), and the NEFRON cohort as a whole (n = 3893).
Indigenous Australians with diabetes had high rates of micro- and macrovascular disease. 60% of Indigenous patients had an abnormal albumin to creatinine ratio compared to 33% of non-Indigenous patients (p < 0.01). When compared to non-Indigenous patients, Indigenous patients were more likely to have established macrovascular disease ((adjusted Odds ratio 2.7). This excess in complications was associated with poor glycemic control, with an HbA1c >or= 8.0%, observed in 55% of all Indigenous patients, despite the similar frequency use of oral antidiabetic agents and insulin. Smoking was also more common in Indigenous patients (38%vs 10%, p < 0.01). However, the achievement of LDL and blood pressure targets was the same or better in Indigenous patients.
Although seeing the same doctors and receiving the same medications, glycaemic and smoking cessation targets remain unfulfilled in Indigenous patients. This cross-sectional study confirms Aboriginal ethnicity as a powerful risk factor for microvascular and macrovascular disease, which practitioners should use to identify candidates for intensive multifactorial intervention.
澳大利亚原住民患糖尿病及其并发症的比例很高。本研究探讨了澳大利亚初级医疗中2型糖尿病患者管理方面的种族差异。
将参加NEFRON研究的原住民患者(n = 144)的糖尿病管理及结局与连续就诊于同一位医生的非原住民患者(n = 449)以及整个NEFRON队列(n = 3893)进行系统比较。
患有糖尿病的澳大利亚原住民微血管和大血管疾病发生率很高。60%的原住民患者白蛋白与肌酐比值异常,而非原住民患者这一比例为33%(p < 0.01)。与非原住民患者相比,原住民患者更易患已确诊的大血管疾病(调整后的优势比为2.7)。尽管口服降糖药和胰岛素的使用频率相似,但这些并发症过多与血糖控制不佳有关,在所有原住民患者中有55%的患者糖化血红蛋白≥8.0%。吸烟在原住民患者中也更常见(38%对10%,p < 0.01)。然而,原住民患者在低密度脂蛋白和血压目标的达成方面相同或更佳。
尽管看同一位医生并接受相同药物治疗,但原住民患者的血糖和戒烟目标仍未实现。这项横断面研究证实,原住民种族是微血管和大血管疾病的一个重要危险因素,医生应用此来识别强化多因素干预的候选对象。