Ng Vivien V, Booth Michael I, Stratford Jane J, Jones Linda, Sohanpal J, Dehn Thomas C B
Department of General Surgery and GI Physiology, Royal Berkshire Hospital, Reading, UK.
Ann R Coll Surg Engl. 2007 Oct;89(7):696-702. doi: 10.1308/003588407X205323.
Obesity has long been regarded as a risk factor for the development of gastro-oesophageal reflux disease (GORD). It has been claimed that surgical efficacy of laparoscopic anti-reflux operations is decreased in obese patients. The aim of this study was to assess whether laparoscopic anti-reflux surgery is effective in obese patients with GORD compared to non-obese patients.
A total of 366 patients (mean age 44 years; range, 12-86 years) underwent laparoscopic anti-reflux surgery between 1997-2003. Of these, 74 patients were considered obese; 58 patients had a body mass index (BMI) of 30-34 kg/m(2) and 16 were classified as morbidly obese with a BMI >or= 35 kg/m(2). Pre-operative symptomatic scoring, indications for surgery, pH studies, operative times and complications were compared between obese and non-obese patients. Symptomatic outcome and Visick score between the two groups were assessed at 6 weeks, 6 months and 1 year following surgery.
Failure of medical treatment was the main reason for surgery in all groups. Operative time was longer in obese patients (mean time 93 min compared to 81 min; P = 0.0007), the main difficulty being gaining access because of their body habitus. All groups found the procedure to be effective in symptomatic outcome, 91% of obese patients compared to 92% of non-obese patients scored Visick I or II at 6 weeks' postoperatively. Similar Visick scoring was shown between the two groups at 6 months and 1 year, and in the morbidly obese group.
The outcome of laparoscopic anti-reflux surgery is similar between obese and non-obese patients with no trend towards a worse outcome in the obese or morbidly obese. Obesity should not be seen as a contra-indication, although it may be more technically challenging in this group of patients. Good results can be achieved in obese patients.
肥胖长期以来一直被视为胃食管反流病(GORD)发病的一个危险因素。有人声称肥胖患者腹腔镜抗反流手术的疗效会降低。本研究的目的是评估与非肥胖患者相比,腹腔镜抗反流手术对肥胖的GORD患者是否有效。
1997年至2003年间,共有366例患者(平均年龄44岁;范围12 - 86岁)接受了腹腔镜抗反流手术。其中,74例患者被认为肥胖;58例患者体重指数(BMI)为30 - 34kg/m²,16例被归类为病态肥胖,BMI≥35kg/m²。比较肥胖和非肥胖患者术前的症状评分、手术指征、pH值研究、手术时间及并发症。在术后6周、6个月和1年评估两组患者的症状结局和Visick评分。
所有组中,药物治疗失败是手术的主要原因。肥胖患者的手术时间更长(平均时间93分钟,而非肥胖患者为81分钟;P = 0.0007),主要困难在于因其体型难以建立手术入路。所有组均发现该手术在改善症状方面有效,术后6周时,91%的肥胖患者和92%的非肥胖患者Visick评分为I或II级。在6个月和1年时,两组以及病态肥胖组的Visick评分相似。
肥胖和非肥胖的GORD患者腹腔镜抗反流手术的结局相似,肥胖或病态肥胖患者并无结局更差的趋势。肥胖不应被视为禁忌证,尽管在这类患者中手术技术上可能更具挑战性。肥胖患者也能取得良好的手术效果。