怀孕和哺乳期小鼠乳腺中的鸟苷酸环化酶和环磷酸鸟苷磷酸二酯酶活性。
Guanylate cyclase and cyclic-GMP phosphodiesterase activities in mammary glands of mice during pregnancy and lactation.
作者信息
Smith R D, Rillema J A
出版信息
Proc Soc Exp Biol Med. 1975 Dec;150(3):763-5. doi: 10.3181/00379727-150-39121.
Guanylate cyclase and cyclic-GMP phosphodiesterase activities were measured in homogenates of mammary glands from virgin, pregnant, and lactating mice. Guanylate cyclase activities increased 35% in mammary tissues during pregnancy, and a further 40% increase was observed during lactation. Cyclic-GMP phosphodiesterase activity also increased during pregnancy but activities were not different in glands from lactating mice vs glands from pregnant mice. These results are discussed with regard to a possible role of cyclic-GMP in regulating lactational processes.
在未孕、怀孕和泌乳小鼠的乳腺匀浆中测量了鸟苷酸环化酶和环磷酸鸟苷磷酸二酯酶的活性。在怀孕期间，乳腺组织中的鸟苷酸环化酶活性增加了35%，在泌乳期间又观察到进一步增加了40%。环磷酸鸟苷磷酸二酯酶活性在怀孕期间也有所增加，但泌乳小鼠的腺体与怀孕小鼠的腺体中的活性没有差异。就环磷酸鸟苷在调节泌乳过程中的可能作用对这些结果进行了讨论。
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