小檗碱是一种天然异喹啉生物碱，可诱导人结肠癌细胞中NAG-1和ATF3的表达。
Berberine, a natural isoquinoline alkaloid, induces NAG-1 and ATF3 expression in human colorectal cancer cells.
作者信息
Piyanuch Rojsanga, Sukhthankar Mugdha, Wandee Gritsanapan, Baek Seung Joon
机构信息
Department of Pathobiology, College of Veterinary Medicine, University of Tennessee, Knoxville, TN 37996, USA.
出版信息
Cancer Lett. 2007 Dec 18;258(2):230-40. doi: 10.1016/j.canlet.2007.09.007. Epub 2007 Oct 25.
Abstract
Berberine is known to possess a wide variety of pharmacological activities, including pro-apoptotic activity. However, its molecular targets are not elucidated at present. NAG-1 and ATF3 are induced by several dietary compounds associated with pro-apoptotic activity. Berberine induces cell growth arrest, apoptosis, NAG-1, and ATF3 in human colorectal cancer cells. ATF3 induction by berberine is mediated in a p53-dependent manner, whereas NAG-1 induction by berberine is mediated by multiple signaling pathways. Our results suggest that berberine facilitates apoptosis and that NAG-1 and ATF3 expression plays an important role in berberine-induced apoptosis.
摘要
已知黄连素具有多种药理活性，包括促凋亡活性。然而，其分子靶点目前尚未阐明。NAG-1和ATF3由几种与促凋亡活性相关的膳食化合物诱导产生。黄连素可诱导人结肠癌细胞的细胞生长停滞、凋亡、NAG-1和ATF3。黄连素对ATF3的诱导是以p53依赖的方式介导的，而黄连素对NAG-1的诱导是由多种信号通路介导的。我们的结果表明，黄连素促进凋亡，并且NAG-1和ATF3的表达在黄连素诱导的凋亡中起重要作用。
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