番荔枝叶乙醇提取物对实验动物的降血糖和抗糖尿病作用
Hypoglycemic and antidiabetic effect of ethanolic extract of leaves of Annona squamosa L. in experimental animals.
作者信息
Gupta Rajesh Kumar, Kesari Achyut Narayan, Murthy P S, Chandra R, Tandon V, Watal Geeta
机构信息
Alternative Therapeutics Unit, Drug Development Division, Medicinal Research Laboratary, Department of Chemistry, University of Allahabad, Allahabad-211002, U.P., India.
出版信息
J Ethnopharmacol. 2005 May 13;99(1):75-81. doi: 10.1016/j.jep.2005.01.048.
The ethanolic extract of Annona squamosa L. (Annonaceae) leaves was administered orally at different doses to normal as well as streptozotocin (STZ)-induced diabetic rats and alloxan-induced diabetic rabbits. The dose of 350 mg/kg body weight (bw) reduced the fasting blood glucose (FBG) level by 6.0% within 1 h, whereas, the peak blood glucose at 1 h during glucose tolerance test (GTT) was reduced by 17.1% in normal rats. The same dose of ethanolic extract reduced FBG by 26.8% and improved glucose tolerance by 38.5 and 40.6% at 1 and 2 h, respectively, during GTT in alloxan-induced diabetic rabbits. In STZ-diabetic rats, a fall of 13.0% in FBG and an improvement in glucose tolerance by 37.2 and 60.6% at 1 and 2 h, respectively, was observed during GTT. The dose of 350 mg/kg bw of ethanolic extract in 10-day treatment of a group of STZ-diabetic rats produced 73.3% fall in FBG level and no sugar was observed in fasting urine. Treatment of severely-diabetic rabbits for 15 days with a dose of 350 mg/kg of extract reduce FBG by 52.7% and urine sugar by 75%. It brought about fall in the level of total cholesterol (TC) by 49.3% with increase of 30.3% in high-density lipoprotein (HDL) and decrease of 71.9 and 28.7% in low-density lipoprotein (LDL) and triglycerides (TG) levels, respectively.
将番荔枝科植物番荔枝（Annona squamosa L.）叶片的乙醇提取物以不同剂量口服给予正常大鼠以及链脲佐菌素（STZ）诱导的糖尿病大鼠和四氧嘧啶诱导的糖尿病兔。体重350 mg/kg的剂量在1小时内使正常大鼠的空腹血糖（FBG）水平降低了6.0%，而在葡萄糖耐量试验（GTT）期间1小时的血糖峰值在正常大鼠中降低了17.1%。相同剂量的乙醇提取物在四氧嘧啶诱导的糖尿病兔的GTT中，1小时和2小时时分别使FBG降低了26.8%，葡萄糖耐量提高了38.5%和40.6%。在STZ诱导的糖尿病大鼠的GTT中，观察到FBG下降了13.0%，1小时和2小时时葡萄糖耐量分别提高了37.2%和60.6%。体重350 mg/kg的乙醇提取物对一组STZ诱导的糖尿病大鼠进行10天治疗后，FBG水平下降了73.3%，空腹尿中未检测到糖分。用350 mg/kg提取物对重度糖尿病兔进行15天治疗后，FBG降低了52.7%，尿糖降低了75%。它使总胆固醇（TC）水平下降了49.3%，高密度脂蛋白（HDL）增加了30.3%，低密度脂蛋白（LDL）和甘油三酯（TG）水平分别下降了71.9%和28.7%。
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