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男女温室工人的生殖系统疾病

Reproductive disorders among male and female greenhouse workers.

作者信息

Bretveld Reini W, Hooiveld Mariëtte, Zielhuis Gerhard A, Pellegrino Annelies, van Rooij Iris A L M, Roeleveld Nel

机构信息

Department of Epidemiology and Biostatistics, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands.

出版信息

Reprod Toxicol. 2008 Jan;25(1):107-14. doi: 10.1016/j.reprotox.2007.08.005. Epub 2007 Sep 11.

Abstract

The aim of this study was to evaluate reproductive disorders in male and female greenhouse workers. In 2002, data were collected from 4872 Dutch greenhouse workers and 8133 referents through postal questionnaires with detailed questions on reproductive disorders of the most recent pregnancy, lifestyle habits, and occupational exposures (e.g. pesticides) prior to conception. Different reproductive outcome measures were compared between 957 male and 101 female greenhouse workers and 1408 referents by means of logistic regression analyses. The analyses of primigravidous couples showed a slightly elevated risk of prolonged TTP (OR(women)=1.9; 95% CI: 0.8-4.4) and an increased risk of spontaneous abortion among female greenhouse workers (OR(women)=4.0; 95% CI: 1.1-14.0). A decreased risk of preterm birth was found among male greenhouse workers (OR(men)=0.1; 95% CI: 0.03-0.5). This study may offer some evidence for the hypothesis that pesticide exposure affects human reproduction leading to spontaneous abortion and possibly to prolonged time-to-pregnancy.

摘要

本研究的目的是评估男性和女性温室工人的生殖障碍情况。2002年,通过邮政问卷从4872名荷兰温室工人和8133名对照者那里收集了数据,问卷包含有关最近一次怀孕的生殖障碍、生活习惯以及受孕前职业暴露(如接触杀虫剂)的详细问题。通过逻辑回归分析,比较了957名男性和101名女性温室工人以及1408名对照者之间不同的生殖结局指标。初孕夫妇的分析显示,女性温室工人出现TTP延长的风险略有升高(OR(女性)=1.9;95%置信区间:0.8 - 4.4),自然流产风险增加(OR(女性)=4.0;95%置信区间:1.1 - 14.0)。男性温室工人早产风险降低(OR(男性)=0.1;95%置信区间:0.03 - 0.5)。本研究可能为以下假设提供一些证据:接触杀虫剂会影响人类生殖,导致自然流产,并可能导致受孕时间延长。

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