特发性佩罗尼氏病与人类白细胞抗原的关联：病因发病机制中自身免疫现象的一个指征？

HLA association of idiopathic Peyronie's disease: an indication of autoimmune phenomena in etiopathogenesis?

作者信息

Rompel R, Weidner W, Mueller-Eckhardt G

机构信息

Institute for Clinical Immunology and Transfusion Medicine, University of Giessen, FRG.

出版信息

Tissue Antigens. 1991 Sep;38(3):104-6. doi: 10.1111/j.1399-0039.1991.tb02021.x.

DOI:10.1111/j.1399-0039.1991.tb02021.x

PMID:1796451

Abstract

HLA typing for class I and class II antigens was done in 52 unrelated patients suffering from idiopathic Peyronie's disease. The controversially discussed association with the HLA-B7 cross-reacting group could not be confirmed. Marked deviations of antigen frequencies were observed for HLA-A1, B8, Cw7, DR3 and DQw2 compared to healthy local controls. After correction of p-values, A1 (pc less than 0.05) and DQw2 (pc less than 0.01) remained significant. A possible association of Peyronie's disease with markers of the HLA-A1, B8, Cw7, DR3, DQw2 haplotype, as first described here, would suggest autoimmunological factors in this disorder of otherwise unknown etiopathogenesis.

摘要

对52例患有特发性佩罗尼氏病的非亲属患者进行了I类和II类抗原的HLA分型。与HLA - B7交叉反应组存在争议的关联未能得到证实。与当地健康对照组相比，观察到HLA - A1、B8、Cw7、DR3和DQw2的抗原频率有明显偏差。校正p值后，A1（校正p值小于0.05）和DQw2（校正p值小于0.01）仍具有显著性。如本文首次所述，佩罗尼氏病与HLA - A1、B8、Cw7、DR3、DQw2单倍型标记物之间可能存在关联，这表明在这种病因不明的疾病中存在自身免疫因素。