Rompel R, Mueller-Eckhardt G, Schroeder-Printzen I, Weidner W
Department of Dermatology, University of Giessen, FRG.
Urol Int. 1994;52(1):34-7. doi: 10.1159/000282566.
This study presents data on HLA phenotypes of 52 unrelated patients suffering from idiopathic Peyronie's disease. This first investigation on HLA class II antigens detected an association of HLA-DR3 and -DQw2 in this disorder. HLA typing was done from ACD-stabilized peripheral blood using the modified lymphocytotoxicity test. Antigen frequencies of the patient group were compared with those of healthy individuals of the local population. There were no deviations of frequencies for antigens of the B7 cross-reacting group as described in earlier studies. In addition none of the other class I antigens (HLA-A, -B, -C) showed any significant deviation in frequencies after correction of p values. Regarding class II antigens HLA-DR3 was detected in the patient group in 33.3% compared with 16.0% of the control population (corrected p < 0.05). The closely linked antigen DQw2 was found in 58.8 compared with 31.2% (corrected p < 0.005). Not only genetic factors can be stated by these findings. As HLA-DR3 and -DQw2 are known to be the typical associated antigens of organospecific autoimmune disorders, this suggests possible autoimmunological factors in this disorder of otherwise unknown etiology.
本研究展示了52例患特发性佩罗尼氏病的非亲属患者的HLA表型数据。这项关于HLA - II类抗原的首次调查发现该疾病与HLA - DR3和 - DQw2存在关联。使用改良淋巴细胞毒性试验对ACD稳定的外周血进行HLA分型。将患者组的抗原频率与当地健康人群的抗原频率进行比较。如早期研究所述，B7交叉反应组的抗原频率没有偏差。此外，在对p值进行校正后，其他I类抗原（HLA - A、 - B、 - C）的频率均未显示出任何显著偏差。关于II类抗原，患者组中检测到HLA - DR3的比例为33.3%，而对照组为16.0%（校正后p < 0.05）。紧密连锁的抗原DQw2在患者组中的发现比例为58.8%，而对照组为31.2%（校正后p < 0.005）。这些发现不仅说明了遗传因素。由于已知HLA - DR3和 - DQw2是器官特异性自身免疫性疾病的典型相关抗原，这表明在这种病因不明的疾病中可能存在自身免疫因素。
