Ralph D J, Schwartz G, Moore W, Pryor J P, Ebringer A, Bottazzo G F
Institute of Urology, St Peter's Hospital, London, England.
J Urol. 1997 Jan;157(1):291-4.
Peyronie's disease has been associated with HLA tissue types, including HLA-A1, DR3, DQw2 and HLA-B7 cross-reactive group antigens which include HLA-B27. This association was tested as was the process of molecular mimicry where the host HLA surface antigen cross-reacts with a microorganism.
HLA tissue typing was performed on 51 white patients with Peyronie's disease, of whom 15 also had Dupuytren's contracture of the hand. Fecal, urine and urethral samples were taken from patients with Peyronie's disease who had proved penile inflammation on biopsy. The samples were cultured for species of Campylobacter, Shigella, Salmonella, Yersinia, Chlamydia and gonococcus, all known to cross-react with the HLA-B27 surface antigen. Antibodies to Klebsiella species, Proteus species and Escherichia coli were also assessed in the sera of 65 patients with Peyronie's disease.
A significant association between Peyronie's disease and HLA-B27 was found (p = 0.02). The remaining antigens of the HLA-B7 group were not significantly associated with the disease individually (HLA-B7 p > 0.2, HLA-B22 p > 0.6, HLA-B40 p > 0.7) or as a group (p = 0.69). The previously found associations did not reach significance in this study (HLA-A1 p > 0.5, HLA-B8 p > 0.2, HLA-Cw7 p = 0.1, HLA-DR3 p > 0.4, HLA-DQ2 p > 0.4). Cultures for all enteric and urethral organisms were negative, and patients with Peyronie's disease did not have elevated serum titers of anti Klebsiella, anti Proteus or anti E. coli antibodies.
Although there is an association between Peyronie's disease and HLA-B27, molecular mimicry does not occur with the organisms tested, and an infectious agent has not been found in this study.
佩罗尼氏病与HLA组织类型有关，包括HLA - A1、DR3、DQw2以及包括HLA - B27在内的HLA - B7交叉反应组抗原。对这种关联以及宿主HLA表面抗原与微生物发生交叉反应的分子模拟过程进行了检测。
对51例患有佩罗尼氏病的白人患者进行HLA组织分型，其中15例还患有手部掌腱膜挛缩症。从经活检证实阴茎有炎症的佩罗尼氏病患者中采集粪便、尿液和尿道样本。对样本进行培养，以检测弯曲杆菌属、志贺氏菌属、沙门氏菌属、耶尔森氏菌属、衣原体属和淋球菌属，所有这些都已知会与HLA - B27表面抗原发生交叉反应。还对65例佩罗尼氏病患者的血清中针对克雷伯氏菌属、变形杆菌属和大肠杆菌的抗体进行了评估。
发现佩罗尼氏病与HLA - B27之间存在显著关联（p = 0.02）。HLA - B7组的其余抗原单独与该疾病无显著关联（HLA - B7 p > 0.2，HLA - B22 p > 0.6，HLA - B40 p > 0.7），作为一组也无显著关联（p = 0.69）。先前发现的关联在本研究中未达到显著水平（HLA - A1 p > 0.5，HLA - B8 p > 0.2，HLA - Cw7 p = 0.1，HLA - DR3 p > 0.4，HLA - DQ2 p > 0.4）。所有肠道和尿道微生物的培养均为阴性，佩罗尼氏病患者的血清中抗克雷伯氏菌、抗变形杆菌或抗大肠杆菌抗体滴度未升高。
虽然佩罗尼氏病与HLA - B27之间存在关联，但在所检测的微生物中未发生分子模拟，且本研究未发现感染因子。
