参与巴氏甲烷八叠球菌中甲基四氢甲烷蝶呤与辅酶M之间甲基转移的含类咕啉酶的还原激活。
Reductive activation of the corrinoid-containing enzyme involved in methyl group transfer between methyl-tetrahydromethanopterin and coenzyme M in Methanosarcina barkeri.
作者信息
van de Wijngaard W M, Lugtigheid R L, van der Drift C
机构信息
Department of Microbiology, Faculty of Science, University of Nijmegen, The Netherlands.
出版信息
Antonie Van Leeuwenhoek. 1991 Jul;60(1):1-6. doi: 10.1007/BF00580434.
The conversion of methyl-tetrahydromethanopterin to methylcoenzyme M in Methanosarcina barkeri is catalyzed by two enzymes: an enzyme with a bound corrinoid, which becomes methylated during the reaction and an enzyme which transfers the methyl group from this corrinoid to coenzyme M. As in the similar methyltransfer reaction in Methanobacterium thermoautotrophicum the corrinoid enzyme in M barkeri needs to be activated by H2 and ATP. ATP can be replaced by Ti(III)citrate or CO.
在巴氏甲烷八叠球菌中，甲基四氢蝶呤向甲基辅酶M的转化由两种酶催化：一种结合类咕啉的酶，该酶在反应过程中发生甲基化；另一种酶则将甲基从该类咕啉转移至辅酶M。与嗜热自养甲烷杆菌中的类似甲基转移反应一样，巴氏甲烷八叠球菌中的类咕啉酶需要被H2和ATP激活。ATP可用柠檬酸钛（III）或CO替代。
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