Lian Xin-Fu, Luo Xiao-Dong
Guangdong Provincial Hospital of Traditional Chi-nese Medicine, Guangdong.
Zhongguo Zhong Xi Yi Jie He Za Zhi. 2007 Sep;27(9):796-9.
To observe the effect of TCM treatment according to syndrome differentiation in en-hancing curative effect and reducing side-effect of madopa in patients with Parkinson' s disease (PD).
The trial was conducted in 101 PD patients with a prospective stratified randomized and controlled method. They were assigned to group 1 in which the patients of rigidity were treated with Pabing Recipe 1 (PR1) plus Madopa tablets, group 2 with those of tremor given Pabing Recipe 3 (PR3) plus Madopa tablets, and group 3 given a fixed Chinese recipe plus Madopa tablets as the control. The treatment course for all the groups was 3 months. Clinical efficacy was evaluated with unified Parkinson's disease rating scale (UPDRS) and the adverse reactions observed before and after treatment.
After treatment, the 4 partial scores and the total score of UPDRS decreased significantly in group 2 (P<0.01), and the former of them and the total score declined in group 1 and 3 (P<0.01), the improvement was better in group 1 and 2 than that in group 3 (P<0.01); the improvement rate in group 1 to 3 was 95.5%, 100.0% and 83.7%, respectively, which was significantly higher in group 1 and 2 than that in group 3 (P<0.05).
TCM treatment according to syndrome differentiation could improve the clinical symptoms and reduce complications in PD patients, which could enhance curative effect and reduce side-effect of madopa.
观察帕金森病（PD）患者采用中医辨证论治配合美多巴治疗在提高疗效及减轻美多巴副作用方面的效果。
采用前瞻性分层随机对照法对101例PD患者进行试验。将患者分为1组，僵直型患者采用帕病1号方（PR1）加美多巴片治疗；2组，震颤型患者采用帕病3号方（PR3）加美多巴片治疗；3组，给予固定中药方加美多巴片作为对照。所有组治疗疗程均为3个月。采用统一帕金森病评定量表（UPDRS）评估临床疗效，并观察治疗前后的不良反应。
治疗后，2组UPDRS的4个部分评分及总分均显著下降（P<0.01），1组和3组的前3个部分评分及总分下降（P<0.01），1组和2组的改善情况优于3组（P<0.01）；1组至3组的改善率分别为95.5%、100.0%和83.7%，1组和2组显著高于3组（P<0.05）。
中医辨证论治可改善PD患者的临床症状，减少并发症，提高美多巴的疗效并减轻其副作用。
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