Pérez-Bermejo Marcelino, Mas-Pérez Irene, Murillo-Llorente Maria Teresa
SONEV Research Group, School of Medicine and Health Sciences, Catholic University of Valencia San Vicente Mártir, C/Quevedo nº 2, 46001 Valencia, Spain.
School of Medicine and Health Sciences, Catholic University of Valencia San Vicente Mártir, C/Quevedo nº 2, 46001 Valencia, Spain.
Biomedicines. 2021 Jun 10;9(6):666. doi: 10.3390/biomedicines9060666.
Bisphenol A is a compound commonly found in products meant for daily use. It was one of the first compounds to be identified as an endocrine disruptor that was capable of disrupting the endocrine system and producing very similar effects to those of metabolic syndrome. It has recently gained popularity in the scientific arena as a risk factor for obesity and diabetes due to its ability to imitate natural oestrogens and bind to their receptors. The aim was to study the possible relationship between the Bisphenol A endocrine disruptor with diabetes and obesity. The analysis of the articles allows us to conclude that Bisphenol A is an additional risk factor to consider in the development of diabetes and obesity, since it is capable of stimulating the hypertrophy of adipocytes and altering the endocrine system by mimicking the effects of the oestrogen molecule, since epidemiological studies carried out have suggested that the same disruptions seen in experimental studies on animals can be found in humans; however, despite many countries having developed policies to limit exposure to this disruptor in their populations, there is a lack of international agreement. Understanding its relationship with obesity and diabetes will help to raise awareness in the population and adopt public health campaigns to prevent exposure-especially among young people-to these substances.
双酚A是一种常见于日常用品中的化合物。它是最早被确认为内分泌干扰物的化合物之一，能够扰乱内分泌系统，并产生与代谢综合征非常相似的影响。由于其能够模仿天然雌激素并与其受体结合，最近在科学界作为肥胖和糖尿病的一个风险因素而受到关注。目的是研究双酚A这种内分泌干扰物与糖尿病和肥胖之间可能存在的关系。对这些文章的分析使我们得出结论，双酚A是糖尿病和肥胖症发展过程中需要考虑的一个额外风险因素，因为它能够刺激脂肪细胞肥大，并通过模拟雌激素分子的作用来改变内分泌系统，因为已开展的流行病学研究表明，在动物实验研究中看到的同样干扰现象在人类中也能发现；然而，尽管许多国家已制定政策限制其民众接触这种干扰物，但仍缺乏国际共识。了解其与肥胖和糖尿病的关系将有助于提高民众的认识，并开展公共卫生运动以防止尤其是年轻人接触这些物质。
