Altrock B W, Cardiff R D, Blair P B
J Natl Cancer Inst. 1981 Jul;67(1):163-8.
Serum reactivity to murine mammary tumor virus (MuMTV) was inversely related to mammary tumor risk in 8-to 22-week-old BALB/cfC3H breeding females. Mice at low tumor risk exhibited high-titered serum reactivity to MuMTV (50% end point, greater than or equal to 1:40 by radioimmunoassay) approximately 3-6 months earlier than did the mice at high tumor risk. Maternal MuMTV antibody levels were correlated with the serum anti-MuMTV reactivity of their neonatal offspring (2 wk of age). Serologic antiviral reactivity in infected mice did not change during periods of pregnancy and lactation. All infected animals had detectable serum MuMTV reactivity by 33 weeks of age. The virus-neutralizing capabilities of some of these sera were tested, Sera from some of the young, low-tumor-risk animals that had MuMTV-precipitating antibodies also had virus-neutralizing activity. Conversely, none of the sera from the high-tumor-risk animals had detectable MuMTV-neutralizing antibodies.
在8至22周龄的BALB/cfC3H繁殖雌性小鼠中，血清对小鼠乳腺肿瘤病毒（MuMTV）的反应性与乳腺肿瘤风险呈负相关。低肿瘤风险的小鼠比高肿瘤风险的小鼠大约早3至6个月表现出对MuMTV的高滴度血清反应性（50%终点，通过放射免疫测定法大于或等于1:40）。母体MuMTV抗体水平与其新生后代（2周龄）的血清抗MuMTV反应性相关。感染小鼠的血清抗病毒反应性在怀孕和哺乳期间没有变化。所有感染动物在33周龄时血清中均可检测到MuMTV反应性。对其中一些血清的病毒中和能力进行了测试，一些具有MuMTV沉淀抗体的年轻、低肿瘤风险动物的血清也具有病毒中和活性。相反，高肿瘤风险动物的血清中均未检测到MuMTV中和抗体。
