外阴前庭炎综合征与口服避孕药的雌激素剂量

Vulvar vestibulitis syndrome and estrogen dose of oral contraceptive pills.

作者信息

Greenstein Alexander, Ben-Aroya Zahi, Fass Orit, Militscher Idan, Roslik Yelena, Chen Juza, Abramov Liora

机构信息

Tel Aviv Sourasky Medical Center - Urology, Tel-Aviv, Israel.

出版信息

J Sex Med. 2007 Nov;4(6):1679-83. doi: 10.1111/j.1743-6109.2007.00621.x.

DOI:10.1111/j.1743-6109.2007.00621.x

PMID:17970976

Abstract

INTRODUCTION

Vulvar vestibulitis syndrome (VVS) is a diverse, multifactorial phenomenon. Its precise etiology is unknown.

AIM

To define the association between oral contraceptive (OC) estrogen dosage and VVS. Methods. Women diagnosed as having VVS participated in the study.

MAIN OUTCOME MEASURES

Data on type and usage of oral contraceptive pills (OC) were obtained by a questionnaire, and they were compared for the data on OC usage in the general population.

RESULTS

Available commercial data on Israeli women taking OC showed that 51% of them use low-dose estrogen (</=20 microg) OC and 49% use higher-dose estrogen (30-35 microg) OC. Of the 132 women in the study, 86 (65%) used OC: 68 (79%) used low-dose estrogen OC (P < 0.002 compared to the general population), while only 18 (21%) used high-dose estrogen OC (P < 0.002 compared to the general population).

CONCLUSION

Significantly more patients who are treated in our clinic for VVS use low-dose estrogen than those who use high-dose estrogen OC.

摘要

引言

外阴前庭炎综合征（VVS）是一种多样的、多因素的现象。其确切病因尚不清楚。

目的

确定口服避孕药（OC）雌激素剂量与VVS之间的关联。方法：诊断为患有VVS的女性参与该研究。

主要观察指标

通过问卷调查获取口服避孕药（OC）的类型和使用数据，并将其与普通人群中OC的使用数据进行比较。

结果

以色列服用OC的女性的现有商业数据显示，其中51%使用低剂量雌激素（≤20微克）OC，49%使用高剂量雌激素（30 - 35微克）OC。在该研究的132名女性中，86名（65%）使用OC：68名（79%）使用低剂量雌激素OC（与普通人群相比，P < 0.002），而只有18名（21%）使用高剂量雌激素OC（与普通人群相比，P < 0.002）。