Carroll K B, Secombe C J, Pepys J
Clin Allergy. 1976 Mar;6(2):99-104. doi: 10.1111/j.1365-2222.1976.tb01886.x.
The production of asthma by toluene di-isocyanate, aspirated into the ventilating system and emanating from the exhausts of a neighbouring factory, was established in three otherwise non-exposed clerical workers. Occupational-type exposure tests with a polyurethane varnish/toluene di-isocyanate mixture elicited vigorous and prolonged non-immediate asthmatic reactions, thus enabling identification of the otherwise, obscure etiological cause of their asthma.
