Burge P S
Eur J Respir Dis Suppl. 1982;123:91-6.
Non-specific bronchial reactivity to histamine has been measured before specific occupational bronchial tests in the following groups: 51 workers exposed to toluene di-isocyanate (TDI); 40 workers exposed to diphenylmethane diisocyanate (MDI); 45 electronics workers exposed to colophony fumes and 13 unexposed controls. Finally 38 electronics workers had repeated measurements after moving their place of work. The results showed that histamine reactivity was an important, but not obligatory, factor in the development of occupational asthma, and that it appeared to be the result rather than the cause of occupational asthma, as it returned towards normal in workers removed from exposure. TDI and MDI were shown to be acting as specific causes of occupational asthma rather than nonspecific irritants at concentrations up to 0.02 ppm. There was evidence that some irritant reactions to colophony were occurring at exposure levels encountered at work, but that the majority of workers with colophony asthma were having specific reactions to the colophony fume.
在以下几组人群中，于特定职业性支气管试验之前测量了对组胺的非特异性支气管反应性：51名接触甲苯二异氰酸酯（TDI）的工人；40名接触二苯基甲烷二异氰酸酯（MDI）的工人；45名接触松香烟雾的电子工人以及13名未接触者作为对照。最后，38名电子工人在更换工作地点后进行了重复测量。结果表明，组胺反应性是职业性哮喘发生的一个重要但非必要因素，而且它似乎是职业性哮喘的结果而非原因，因为脱离接触的工人其反应性会恢复正常。已表明，在浓度高达0.02 ppm时，TDI和MDI是职业性哮喘的特异性病因，而非非特异性刺激物。有证据表明，在工作中遇到的接触水平下会发生一些对松香的刺激反应，但大多数患松香哮喘的工人对松香烟雾有特异性反应。
