苍白球深部脑刺激改善节段性和全身性肌张力障碍患者的生活质量：一项前瞻性、随机、假手术对照试验的结果

Pallidal deep brain stimulation improves quality of life in segmental and generalized dystonia: results from a prospective, randomized sham-controlled trial.

作者信息

Mueller Joerg, Skogseid Inger M, Benecke Reiner, Kupsch Andreas, Trottenberg Thomas, Poewe Werner, Schneider Gerd H, Eisner Wilhelm, Wolters Alexander, Müller J U, Deuschl Günther, Pinsker Marcus O, Roeste Geir K, Vollmer-Haase Juliane, Brentrup Angela, Krause Martin, Tronnier Volker, Schnitzler Alfons, Voges Jüergen, Nikkhah Guido, Vesper Jan, Naumann Markus, Volkmann Jens

出版信息

Mov Disord. 2008 Jan;23(1):131-4. doi: 10.1002/mds.21783.

DOI:10.1002/mds.21783

PMID:17973330

Abstract

As part of the first randomized, sham-stimulation controlled trial on deep brain stimulation (DBS) in primary segmental or generalized dystonia, health-related quality of life (HRQoL) was assessed by SF-36. After the 3-month sham-controlled phase, significant HRQoL improvement occurred only in the active-stimulation group. The open-label extension phase resulted in a significant improvement in all SF-36 domains following 6 months of neurostimulation. These results demonstrate a favorable impact of DBS on HRQoL in primary dystonia.

摘要

作为首个针对原发性节段性或全身性肌张力障碍进行深部脑刺激（DBS）的随机、假刺激对照试验的一部分，通过SF-36评估了健康相关生活质量（HRQoL）。在为期3个月的假刺激对照阶段后，仅在主动刺激组中出现了HRQoL的显著改善。开放标签延长期在神经刺激6个月后导致所有SF-36领域都有显著改善。这些结果表明DBS对原发性肌张力障碍的HRQoL有积极影响。