苍白球深部脑刺激治疗原发性肌张力障碍中频率的影响。
The effects of frequency in pallidal deep brain stimulation for primary dystonia.
作者信息
Kupsch A, Klaffke S, Kühn A A, Meissner W, Arnold G, Schneider G H, Maier-Hauff K, Trottenberg T
机构信息
Dept. of Neurology, Charité, Campus Virchow, Humboldt University Berlin, Augustenburger Platz 1, 13353 Berlin, Germany.
出版信息
J Neurol. 2003 Oct;250(10):1201-5. doi: 10.1007/s00415-003-0179-0.
The effect of stimulation frequency for pallidal deep brain stimulation in five patients with either generalized or segmental dystonia was evaluated three to twelve months postoperatively via a randomized, double-blind paradigm. The quality of life and the severity of dystonic symptoms improved by approximately 60% and 43% respectively using a frequency of 130 Hz. Compared with 130 Hz a significant further clinical improvement was observed at frequencies of 180 and 250 Hz, which contrasted with a significant deterioration at lower frequencies (5, 50 Hz) compared to 130 Hz.
通过随机双盲模式，对5例全身性或节段性肌张力障碍患者在苍白球深部脑刺激术后3至12个月时刺激频率的效果进行了评估。使用130Hz频率时，生活质量和肌张力障碍症状的严重程度分别改善了约60%和43%。与130Hz相比，在180Hz和250Hz频率时观察到临床有显著进一步改善，而与130Hz相比，较低频率（5Hz、50Hz）时则出现显著恶化。
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