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基于碳纳米管网络的场效应晶体管对DNA的传感

DNA sensing by field-effect transistors based on networks of carbon nanotubes.

作者信息

Gui Ee Ling, Li Lain-Jong, Zhang Keke, Xu Yangping, Dong Xiaochen, Ho Xinning, Lee Pooi See, Kasim Johnson, Shen Z X, Rogers John A, Mhaisalkar S G

机构信息

School of Materials Science and Engineering, Nanyang Technological University 50, Nanyang Avenue, Singapore, 639798.

出版信息

J Am Chem Soc. 2007 Nov 21;129(46):14427-32. doi: 10.1021/ja075176g. Epub 2007 Oct 31.

Abstract

We report on the sensing mechanism of electrical detection of deoxyribonucleic acid (DNA) hybridization for Au- and Cr-contacted field effect transistors based on single-walled carbon nanotube (SWCNT) networks. Barrier height extraction via low-temperature electrical measurement provides direct evidence for the notion that the energy level alignment between electrode and SWCNTs can be affected by DNA immobilization and hybridization. The study of location-selective capping using photoresist provides comprehensive evidence that the sensing of DNA is dominated by the change in metal-SWCNT junctions rather than the channel conductance.

摘要

我们报道了基于单壁碳纳米管(SWCNT)网络的金和铬接触场效应晶体管对脱氧核糖核酸(DNA)杂交进行电学检测的传感机制。通过低温电学测量提取势垒高度,为电极与SWCNT之间的能级排列会受到DNA固定和杂交影响这一观点提供了直接证据。使用光刻胶进行位置选择性封端的研究提供了全面证据,表明DNA传感主要由金属 - SWCNT结的变化而非沟道电导主导。

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