Kim Taemin, Cho Myeongki, Yu Ki Jun
School of Electrical Engineering, Yonsei University, Seoul 03722, Korea.
Materials (Basel). 2018 Jul 8;11(7):1163. doi: 10.3390/ma11071163.
Scientific and engineering progress associated with increased interest in healthcare monitoring, therapy, and human-machine interfaces has rapidly accelerated the development of bio-integrated multifunctional devices. Recently, compensation for the cons of existing materials on electronics for health care systems has been provided by carbon-based nanomaterials. Due to their excellent mechanical and electrical properties, these materials provide benefits such as improved flexibility and stretchability for conformal integration with the soft, curvilinear surfaces of human tissues or organs, while maintaining their own unique functions. This review summarizes the most recent advanced biomedical devices and technologies based on two most popular carbon based materials, carbon nanotubes (CNTs) and graphene. In the beginning, we discuss the biocompatibility of CNTs and graphene by examining their cytotoxicity and/or detrimental effects on the human body for application to bioelectronics. Then, we scrutinize the various types of flexible and/or stretchable substrates that are integrated with CNTs and graphene for the construction of high-quality active electrode arrays and sensors. The convergence of these carbon-based materials and bioelectronics ensures scalability and cooperativity in various fields. Finally, future works with challenges are presented in bio-integrated electronic applications with these carbon-based materials.
随着对医疗保健监测、治疗以及人机接口的兴趣增加，相关的科学和工程进展迅速推动了生物集成多功能设备的发展。最近，碳基纳米材料弥补了现有医疗保健系统电子材料的缺点。由于其优异的机械和电学性能，这些材料具有诸多优势，比如在与人体组织或器官的柔软、曲线表面进行保形集成时，能提高柔韧性和拉伸性，同时保持自身独特功能。本综述总结了基于两种最常用碳基材料——碳纳米管（CNT）和石墨烯的最新先进生物医学设备及技术。首先，我们通过研究碳纳米管和石墨烯在生物电子学应用中的细胞毒性和/或对人体的有害影响，来探讨它们的生物相容性。然后，我们详细考察与碳纳米管和石墨烯集成的各种柔性和/或可拉伸基板，用于构建高质量的有源电极阵列和传感器。这些碳基材料与生物电子学的融合确保了在各个领域的可扩展性和协同性。最后，介绍了在这些碳基材料的生物集成电子应用中面临挑战的未来工作。
