Barre François-Xavier
CNRS, Centre de Génétique Moléculaire, UPR 2167, 91198 Gif-sur-Yvette, France; Univ Paris-Sud, 910405 Orsay, France.
Mol Microbiol. 2007 Dec;66(5):1051-5. doi: 10.1111/j.1365-2958.2007.05981.x. Epub 2007 Oct 31.
During Bacillus subtilis sporulation, the SpoIIIE DNA translocase moves a trapped chromosome across the sporulation septum into the forespore. The preferential assembly of SpoIIIE complexes in the mother cell provided the idea that SpoIIIE functioned as a DNA exporter, which ensured translocation orientation. In this issue of Molecular Microbiology, Becker and Pogliano reinvestigate the molecular mechanisms that orient the activity of SpoIIIE. Their findings indicate that SpoIIIE reads the polarity of DNA like its Escherichia coli homologue, FtsK.
在枯草芽孢杆菌形成芽孢的过程中，SpoIIIE DNA转位酶将一条被困的染色体穿过芽孢形成隔膜转运至前芽孢中。SpoIIIE复合物在母细胞中的优先组装提出了这样一种观点，即SpoIIIE作为一种DNA输出蛋白发挥作用，从而确保转位方向。在本期《分子微生物学》中，贝克尔和波利亚诺重新研究了确定SpoIIIE活性方向的分子机制。他们的研究结果表明，SpoIIIE与其大肠杆菌同源物FtsK一样，能够识别DNA的极性。
