Bogdanović R, Gligić A, Nikolić V, Ognjanović M
Srp Arh Celok Lek. 1995 Jan-Feb;123(1-2):12-7.
During an outbreak of haemorrhagic fever with renal syndrome (HFRS) in 1989, five children (3 girls, 2 boys, aged 6.8-16 years) with severe clinical form of the disease, were treated at the Institute of Mother and Child Health of Serbia; four of them were followed-up 22-28 months thereafter. The main clinical features were: fever, headache, myalgia, abdominal and back pains, and vomiting in all, and haemorrhagic syndrome in three; renal syndrome with severe acute renal failure in all five patients. All the patients recovered. Serological confirmation by an indirect immunofluorescence assay, enzyme immunoassay for IgM antibodies, and by plaque reduction neutralization test revealed that the infection was caused by Belgrade virus in three, and by Hantaan virus in two patients. It was not possible to differentiate these two serogroups on the basis of clinical features. This finding gave further evidence of circulation of different hantaviruses causing severe HFRS in Serbia.
1989年肾综合征出血热（HFRS）暴发期间，塞尔维亚母婴健康研究所对5名患有该疾病严重临床症状的儿童（3名女孩，2名男孩，年龄6.8 - 16岁）进行了治疗；其中4名儿童随后接受了22 - 28个月的随访。主要临床特征为：所有人均有发热、头痛、肌痛、腹痛和背痛以及呕吐症状，3人出现出血综合征；所有5名患者均患有伴有严重急性肾衰竭的肾综合征。所有患者均康复。通过间接免疫荧光试验、IgM抗体酶免疫测定以及蚀斑减少中和试验进行的血清学确认显示，3例感染由贝尔格莱德病毒引起，2例由汉坦病毒引起。根据临床特征无法区分这两个血清群。这一发现进一步证明了在塞尔维亚存在不同汉坦病毒引起严重HFRS的传播情况。
