Weaver Beth A A, Cleveland Don W
Ludwig Institute for Cancer Research and Department of Cellular and Molecular Medicine, University of California at San Diego, La Jolla, CA 92093-0670, USA.
Cancer Res. 2007 Nov 1;67(21):10103-5. doi: 10.1158/0008-5472.CAN-07-2266.
Aneuploidy, an aberrant chromosome number, has been recognized as a common characteristic of cancer cells for more than 100 years and has been suggested as a cause of tumorigenesis for nearly as long. However, this proposal had remained untested due to the difficulty of selectively generating aneuploidy without causing other damage. Using Cenp-E heterozygous animals, which develop whole chromosome aneuploidy in the absence of other defects, we have found that aneuploidy promotes tumorigenesis in some contexts and inhibits it in others. These findings confirm that aneuploidy can act oncogenically and reveal a previously unsuspected role for aneuploidy as a tumor suppressor.
非整倍体，即染色体数目异常，100多年来一直被认为是癌细胞的一个常见特征，并且近100年来一直被认为是肿瘤发生的一个原因。然而，由于难以在不造成其他损伤的情况下选择性地产生非整倍体，这一观点一直未得到验证。利用在没有其他缺陷的情况下会发生整条染色体非整倍体的Cenp-E杂合动物，我们发现非整倍体在某些情况下促进肿瘤发生，而在其他情况下则抑制肿瘤发生。这些发现证实了非整倍体可以发挥致癌作用，并揭示了非整倍体作为肿瘤抑制因子这一先前未被怀疑的作用。
