Slominski Andrzej
Department of Pathology and Laboratory Medicine, Health Science Center, University of Tennessee, Memphis, Tennessee 38163, USA.
J Clin Invest. 2007 Nov;117(11):3166-9. doi: 10.1172/JCI33508.
In this issue of the JCI, Aberg and colleagues report that psychological stress disrupts the skin's antimicrobial barrier and increases the severity of cutaneous infections (see the related article beginning on page 3339). This effect is mediated by endogenous glucocorticoids produced secondarily to stress-related activation of the hypothalamic-pituitary-adrenal axis. Thus, this study provides what I believe to be the first mechanistic link between psychological stress and increased susceptibility to microbial infection.
在本期《临床研究杂志》中,阿伯格及其同事报告称,心理压力会破坏皮肤的抗菌屏障,并加重皮肤感染的严重程度(见第3339页开始的相关文章)。这种效应是由下丘脑-垂体-肾上腺轴应激相关激活继发产生的内源性糖皮质激素介导的。因此,这项研究提供了我认为心理压力与微生物感染易感性增加之间的首个机制联系。