Onorati Francesco, Pezzo Francesco, Comi Maria Caterina, Impiombato Barbara, Esposito Antonio, Polistina Massimo, Renzulli Attilio
Cardiac Surgery Unit, Magna Graecia University of Catanzaro, Catanzaro, Italy.
J Thorac Cardiovasc Surg. 2007 Nov;134(5):1112-20. doi: 10.1016/j.jtcvs.2007.06.007.
Extensive arterial grafting with the radial artery in elderly patients is still debated, because of the reduced life expectancy and the supposedly higher periprocedural morbidity caused by an accelerated atherosclerosis of arterial grafts in elderly patients, which might hamper functional results.
We reviewed our experience with patients undergoing radial artery myocardial revascularization (coronary artery bypass grafting) between January 2003 and December 2006, divided into 2 groups: elderly patients (> or =70 years, group A) and young patients (< or =60 years, group B). Hospital outcome and transit-time flowmetric maximum and mean flow, pulsatility index, and graft flow reserve were compared. Results were stratified by target vessel, surgical technique, and subgroups at risk.
Hospital outcome, troponin I levels, and echocardiographic segmental kinetics were comparable in the 2 groups. Stratifying patients for target vessels, no differences in radial artery transit-time flowmetric results were recorded between the 2 groups either on-pump or off-pump, as free grafts or Y grafts, or in diabetic patients and hypertensive patients. Although graft flow reserve was significantly improved in all patients (P < .05 in the young and elderly groups, regardless of the target vessel, the surgical technique, and the comorbidities), graft flow reserve of radial artery grafts was comparable between elderly and young patients.
Radial artery coronary artery bypass grafting showed similar transit-time flowmetric functional results in elderly and young patients, regardless of the target vessel, the use or avoidance of cardiopulmonary bypass, the construction of proximal anastomoses, and the presence of comorbidities. These data explain the reported better results of arterial revascularization in the elderly and suggest an increase in extensive radial artery grafting in the last decades of life.
老年患者广泛使用桡动脉进行动脉移植仍存在争议,因为预期寿命缩短以及老年患者动脉移植加速动脉粥样硬化可能导致更高的围手术期发病率,这可能会影响功能结果。
我们回顾了2003年1月至2006年12月期间接受桡动脉心肌血运重建术(冠状动脉旁路移植术)患者的经验,分为两组:老年患者(≥70岁,A组)和年轻患者(≤60岁,B组)。比较了住院结局、通过时间血流测量的最大和平均流量、搏动指数以及移植血管血流储备。结果按靶血管、手术技术和高危亚组进行分层。
两组的住院结局、肌钙蛋白I水平和超声心动图节段动力学相当。按靶血管对患者进行分层,两组在体外循环或非体外循环下,作为游离移植血管或Y形移植血管,以及在糖尿病患者和高血压患者中,桡动脉通过时间血流测量结果均无差异。尽管所有患者的移植血管血流储备均显著改善(年轻组和老年组P均<0.05,无论靶血管、手术技术和合并症如何),但老年患者和年轻患者桡动脉移植血管的血流储备相当。
无论靶血管如何、是否使用体外循环、近端吻合口的构建以及合并症的存在,桡动脉冠状动脉旁路移植术在老年患者和年轻患者中显示出相似的通过时间血流测量功能结果。这些数据解释了老年患者动脉血运重建报告的更好结果,并表明在生命的最后几十年中广泛使用桡动脉移植有所增加。