终身运动与晚年运动对小脑氧化应激影响的比较。
Comparison of lifelong and late life exercise on oxidative stress in the cerebellum.
作者信息
Cui Li, Hofer Tim, Rani Asha, Leeuwenburgh Christiaan, Foster Thomas C
机构信息
Department of Neuroscience, Evelyn F. & William L. McKnight Brain Institute, University of Florida College of Medicine, PO Box 100244, Gainesville, FL 32610-0244, USA.
出版信息
Neurobiol Aging. 2009 Jun;30(6):903-9. doi: 10.1016/j.neurobiolaging.2007.09.005. Epub 2007 Nov 5.
Abstract
Aging was associated with increased oxidation of DNA, RNA, and lipids in the cerebellum of male rats. DNA and lipid oxidation was reduced by lifelong (94 weeks) voluntary exercise on a running wheel. A reduction in cerebellar lipid oxidation, but not RNA or DNA oxidation, was observed following 3 months of moderate exercise or dietary supplementation of vitamin E, initiated at 18 months of age. The level of lipid oxidation correlated with measures of forelimb grip strength. The results indicate that lifelong exercise attenuates multiple molecular markers of age-related oxidative damage in the cerebellum. In addition, modest exercise initiated late in life can have a beneficial effect on lipid oxidation and motor function.
摘要
衰老与雄性大鼠小脑内DNA、RNA和脂质氧化增加有关。终身（94周）在跑步轮上进行自愿运动可减少DNA和脂质氧化。在18月龄开始进行3个月的适度运动或膳食补充维生素E后，观察到小脑脂质氧化减少，但RNA或DNA氧化未减少。脂质氧化水平与前肢握力测量值相关。结果表明，终身运动可减轻小脑中与年龄相关的氧化损伤的多种分子标志物。此外，在生命后期开始的适度运动可对脂质氧化和运动功能产生有益影响。
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