Miyazono Agasa, Yamada Atsushi, Morimura Naoko, Takami Masamichi, Suzuki Dai, Kobayashi Makoto, Tezuka Ken-Ichi, Yamamoto Matsuo, Kamijo Ryutaro
Department of Biochemistry, School of Dentistry, Showa University, 1-5-8 Hatanodai, Shinagawa, Tokyo 142-8555, Japan.
FEBS Lett. 2007 Nov 13;581(27):5321-6. doi: 10.1016/j.febslet.2007.10.021. Epub 2007 Oct 23.
POEM, also called nephronectin, is an extracellular matrix protein that is considered to play a critical role as an adhesion molecule in the development and functioning of various tissues, such as kidneys and bones. In the present study, we examined the molecular mechanism of POEM gene expression, and found that transforming growth factor-beta (TGF-beta) strongly inhibited POEM expression in the mouse osteoblastic cell line, MC3T3-E1. TGF-beta-induced decrease of POEM expression occurred in both time- and dose-dependent manners through the activation of TGF-beta receptor I and extracellular signal-regulated kinase/c-Jun N-terminal kinase pathways.
POEM，也称为肾连蛋白，是一种细胞外基质蛋白，被认为作为一种黏附分子在各种组织（如肾脏和骨骼）的发育和功能中发挥关键作用。在本研究中，我们研究了POEM基因表达的分子机制，发现转化生长因子-β（TGF-β）强烈抑制小鼠成骨细胞系MC3T3-E1中的POEM表达。TGF-β诱导的POEM表达降低通过TGF-β受体I和细胞外信号调节激酶/c-Jun N端激酶途径的激活以时间和剂量依赖性方式发生。
