大脑中的非编码RNA
Noncoding RNAs in the brain.
作者信息
Satterlee John S, Barbee Scott, Jin Peng, Krichevsky Anna, Salama Sofie, Schratt Gerhard, Wu Da-Yu
机构信息
Division of Basic Neuroscience and Behavioral Research, National Institute on Drug Abuse, Bethesda, Maryland 20892, USA.
出版信息
J Neurosci. 2007 Oct 31;27(44):11856-9. doi: 10.1523/JNEUROSCI.3624-07.2007.
Abstract
Cells transcribe thousands of RNAs that do not appear to encode proteins. The neuronal functions of these noncoding RNAs (ncRNAs) are for the most part not known, but specific ncRNAs have been shown to regulate dendritic spine development, neuronal fate specification and differentiation, and synaptic protein synthesis. ncRNAs have been implicated in a number of neuronal diseases including Tourette's syndrome and Fragile X syndrome. Future studies will likely identify additional neuronal functions for ncRNAs as well as roles for these molecules in other neuropsychiatric and neurodevelopmental disorders.
摘要
细胞转录出数千种似乎不编码蛋白质的RNA。这些非编码RNA（ncRNA）的神经元功能大多尚不清楚，但已表明特定的ncRNA可调节树突棘发育、神经元命运特化与分化以及突触蛋白合成。ncRNA与包括妥瑞氏综合征和脆性X综合征在内的多种神经元疾病有关。未来的研究可能会确定ncRNA的其他神经元功能，以及这些分子在其他神经精神和神经发育障碍中的作用。
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