Ito Y, Iguchi Y, Kashiwagi T, Imanishi Y
Department of Polymer Chemistry, Kyoto University, Japan.
J Biomed Mater Res. 1991 Nov;25(11):1347-61. doi: 10.1002/jbm.820251104.
Synthesis of nonthrombogenic materials without using biologically active substances was explored. Poly(sodium vinyl sulfonate) is a water-soluble synthetic polymer and activates antithrombin III to exert nonthrombogenicity that was dependent on the molecular weight. Polyetherurethaneurea film was plasma-treated and graft-polymerized with sodium vinyl sulfonate. The graft film showed excellent in vitro and ex vivo nonthrombogenicity by suppressing interactions with plasma proteins and platelets as well as by inactivating blood-clotting factors.
探索了不使用生物活性物质合成非血栓形成材料的方法。聚（乙烯基磺酸钠）是一种水溶性合成聚合物，可激活抗凝血酶III以发挥取决于分子量的非血栓形成性。聚醚聚氨酯脲薄膜经过等离子体处理并与乙烯基磺酸钠接枝聚合。该接枝薄膜通过抑制与血浆蛋白和血小板的相互作用以及使凝血因子失活，表现出优异的体外和离体非血栓形成性。
