人肠道细菌将肠二醇对映选择性氧化为肠内酯。

Enantioselective oxidation of enterodiol to enterolactone by human intestinal bacteria.

作者信息

Jin Jong-Sik, Kakiuchi Nobuko, Hattori Masao

机构信息

Institute of Natural Medicine, University of Toyama, 2630 Sugitani, Toyama, Japan.

出版信息

Biol Pharm Bull. 2007 Nov;30(11):2204-6. doi: 10.1248/bpb.30.2204.

DOI:10.1248/bpb.30.2204

PMID:17978502

Abstract

In the course of our experiments on the metabolic conversion of lignans to the estrogenic substances enterodiol (END) and enterolactone (ENL) by human intestinal flora, we isolated two anaerobes, Ruminococcus sp. END-1 and strain END-2, capable of oxidizing END. The former selectively converted (-)-END to (-)-ENL, while the latter selectively converted (+)-END to (+)-ENL, indicating enantioselective oxidation by intestinal bacteria.

摘要

在我们关于人肠道菌群将木脂素代谢转化为雌激素类物质肠二醇（END）和肠内酯（ENL）的实验过程中，我们分离出了两种厌氧菌，即瘤胃球菌属END-1菌株和END-2菌株，它们能够氧化END。前者将（-）-END选择性地转化为（-）-ENL，而后者将（+）-END选择性地转化为（+）-ENL，这表明肠道细菌存在对映选择性氧化作用。