Institute of Natural Medicine, University of Toyama, Toyama, Japan.
Biol Pharm Bull. 2010;33(8):1443-7. doi: 10.1248/bpb.33.1443.
A human intestinal bacterium, strain END-2, which enantioselectively oxidizes (+)-enterodiol (END) to (+)-enterolactone (ENL) through enterolactol is also responsible for demethylation during plant lignan metabolism. A free hydroxyl group adjacent to the methoxy group is required for demethylation. The bacterium transformed (+)- and (-)-secoisolariciresinol to (+)-ENL and (-)-END, respectively, by co-incubation with strain ARC-1, which is responsible for dehydroxylation.
一种人类肠道细菌，菌株 END-2，通过肠内乳糖选择性地将 (+)-表儿茶素（END）氧化为 (+)-肠内酯（ENL），也负责植物木质素代谢过程中的脱甲基化。脱甲基化需要甲氧基旁边的游离羟基。该细菌与负责脱羟的菌株 ARC-1 共培养，分别将 (+)-和 (-)-开环异落叶松脂素转化为 (+)-ENL 和 (-)-END。
