Kim Eun-Sun, Chung Woo-Chul, Lee Kang-Moon, Lee Bo-In, Choi Hwang, Han Sok-Won, Choi Kyu-Yong, Chung In-Sik
Department of Internal Medicine, College of Medicine, The Catholic University of Korea, Suwon, Korea.
J Korean Med Sci. 2007 Oct;22(5):918-22. doi: 10.3346/jkms.2007.22.5.918.
Behcet's disease is a multi-systemic vasculitis and characterized by systemic organ involvement. Although the gastrointestinal and systemic features of Behcet's disease and inflammatory bowel disease overlap to a considerable extent, they are generally viewed as two distinct diseases. A 39-yr-old female was diagnosed as having Behcet's disease. She was admitted to our hospital because of oral and genital ulcer, lower abdominal pain, and frequent diarrhea. Colonoscopy showed diffuse involvement of multiple longitudinal ulcers with inflammatory pseudopolyps with a cobblestone appearance and ano-rectal fistula was suspected. These findings are extremely rare in Behcet's disease. However, there were no granulomas, the hallmark of Crohn's colitis. Microscopically, perivasculitis and multiple lymph follicles compatible with Behcet's disease were seen. Although being rarely encountered, multiple longitudinal ulcers, cobblestone appearance, and ano-rectal fistula can develop in Behcet's disease, as in Crohn's colitis. Therefore, Behcet's disease and Crohn's disease may be closely related and part of a spectrum of disease.
白塞病是一种多系统血管炎，其特征为全身器官受累。尽管白塞病的胃肠道和全身特征与炎症性肠病在很大程度上重叠，但它们通常被视为两种不同的疾病。一名39岁女性被诊断为白塞病。她因口腔溃疡、生殖器溃疡、下腹痛和频繁腹泻入院。结肠镜检查显示多个纵向溃疡弥漫性受累，伴有炎性假息肉，呈鹅卵石样外观，怀疑有肛门直肠瘘。这些表现在白塞病中极为罕见。然而，没有肉芽肿，而肉芽肿是克罗恩结肠炎的标志。显微镜下可见与白塞病相符的血管周围炎和多个淋巴滤泡。虽然很少见，但白塞病也可出现多个纵向溃疡、鹅卵石样外观和肛门直肠瘘，如同克罗恩结肠炎一样。因此，白塞病和克罗恩病可能密切相关，属于疾病谱的一部分。
