Vaage J, Valen G
Division of Thoracic and Cardiovascular Surgery, University Hospital, Tromsø.
Klin Wochenschr. 1991 Dec 15;69(21-23):1066-72. doi: 10.1007/BF01645160.
Cardiac surgical complications may be caused by a plethora of events. Oxygen free radicals may participate in the pathophysiology of cardiopulmonary bypass and myocardial ischaemia-reperfusion injury. The evidence of free radical production during bypass is limited, and studies of the effect of free radical scavengers even more limited. Experimental work points towards a role of oxygen free radicals in reperfusion damage of the ischaemic myocardium, but clinical data are lacking. Hitherto the clinical availability of free radical scavengers/antioxidants has been scarse. At present more such drugs are becoming clinically applicable, and trials on their effect are highly warranted, in particular as an adjuvant in myocardial protection.
心脏手术并发症可能由多种事件引起。氧自由基可能参与体外循环和心肌缺血-再灌注损伤的病理生理过程。体外循环期间自由基产生的证据有限，而关于自由基清除剂作用的研究甚至更少。实验研究表明氧自由基在缺血心肌的再灌注损伤中起作用，但缺乏临床数据。迄今为止，自由基清除剂/抗氧化剂在临床上的应用很少。目前，越来越多这类药物开始在临床上适用，因此非常有必要对其效果进行试验，特别是作为心肌保护的辅助手段。
