Toledo-Pereyra L H
Department of Transplantation, Borgess Medical Center, Kalamazoo.
Klin Wochenschr. 1991 Dec 15;69(21-23):1099-104. doi: 10.1007/BF01645165.
This work studies some of the advances that have participated in the development of the liver transplantation-reperfusion injury. This lesion is a rather complex one that probably is not only associated with the production of free radicals, but also of other vasoactive substances such as, prostanoids, altered calcium related compounds, abnormal coagulation factors, as well as other important potentially harmful substances. Our interest since 1975, has resided in compounds that modify the xanthine oxidase pathway, such as allopurinol, that might either protect from the formation of free radicals or might act through other mechanisms such as, purine salvage and production of high energy compounds, among few of them. The pharmacological manipulation of the reperfusion injury, will require in this way, the use of various substances in the protection of the transplanted liver.
这项工作研究了参与肝移植再灌注损伤发展过程的一些进展。这种损伤相当复杂，可能不仅与自由基的产生有关，还与其他血管活性物质有关，如前列腺素、钙相关化合物改变、异常凝血因子以及其他重要的潜在有害物质。自1975年以来，我们一直关注能改变黄嘌呤氧化酶途径的化合物，如别嘌呤醇，它可能要么防止自由基的形成，要么通过其他机制起作用，如嘌呤补救和高能化合物的产生等。如此一来，对再灌注损伤的药物调控将需要使用各种物质来保护移植的肝脏。
