Gibbons Robert V, Kalanarooj Siripen, Jarman Richard G, Nisalak Ananda, Vaughn David W, Endy Timothy P, Mammen Mammen P, Srikiatkhachorn Anon
Department of Virology, United States Army Medical Component-Armed Forces Research Institute of Medical Sciences, Bangkok, Thailand.
Am J Trop Med Hyg. 2007 Nov;77(5):910-3.
Immunity to a single dengue virus (DENV) infection does not provide heterologous immunity to subsequent infection. In fact, the greatest risk for dengue hemorrhagic fever (DHF) is with a second DENV serotype exposure. The risk for DHF with a third or fourth dengue infection relative to a first or second exposure is not known. An analysis of our database of children admitted to the Queen Sirikit National Institute of Child Health and Kamphaeng Phet Provincial Hospital with suspected dengue illness revealed that the number of dengue admissions caused by a third or fourth DENV infection was extremely low (0.08-0.8%). Once admitted, the risk for DHF relative to dengue fever was not different for those experiencing third or fourth DENV infections over those experiencing a second DENV infection. We document new dengue serotype infection sequences leading to DHF of 1-4, 2-3, 3-1, and 3-4.
对单一登革病毒（DENV）感染产生的免疫力并不能为后续感染提供异源免疫。事实上，登革出血热（DHF）的最大风险在于第二次接触DENV血清型。第三次或第四次登革热感染相对于第一次或第二次接触感染DHF的风险尚不清楚。对我们数据库中因疑似登革热疾病入住诗丽吉王后国家儿童健康研究所和甘烹碧省医院的儿童进行分析发现，第三次或第四次DENV感染导致的登革热住院人数极低（0.08 - 0.8%）。一旦入院，第三次或第四次DENV感染患者相对于登革热患者发生DHF的风险与第二次DENV感染患者并无差异。我们记录了导致1 - 4、2 - 3、3 - 1和3 - 4型DHF的新的登革热血清型感染序列。
