用于治疗帕金森病的神经营养因子。

Neurotrophic factors for the treatment of Parkinson's disease.

机构信息

Department of Anatomy/Neuroscience, University College Cork, College Road, Cork, Ireland.

出版信息

Cytokine Growth Factor Rev. 2011 Jun;22(3):157-65. doi: 10.1016/j.cytogfr.2011.05.001.

DOI:10.1016/j.cytogfr.2011.05.001

Abstract

Parkinson's disease (PD) is a common neurodegenerative disorder caused by the progressive degeneration of the nigrostriatal dopaminergic pathway. The resulting loss of dopamine neurotransmission is responsible for the symptoms of the disease. Available treatments are initially successful in treating PD symptoms; however, their long-term use is associated with complications and they cannot stop the neurodegeneration. Current research aims at developing new therapies to halt/reverse the neurodegenerative process, rather than treating symptoms. Neurotrophic factors are proteins critical for maintenance and protection of neurones in the developing and adult brain. Several neurotrophic factors have been investigated for their protective effects on dopaminergic neurones. Here we review some of the most promising factors and provide an update on their status in clinical trials.

摘要

帕金森病（PD）是一种常见的神经退行性疾病，由黑质纹状体多巴胺能通路的进行性退化引起。多巴胺神经递质传递的丧失是导致疾病症状的原因。现有的治疗方法在治疗 PD 症状方面最初是成功的；然而，它们的长期使用与并发症有关，并且不能阻止神经退行性变。目前的研究旨在开发新的治疗方法来阻止/逆转神经退行性过程，而不是治疗症状。神经营养因子是对发育中和成年大脑中的神经元的维持和保护至关重要的蛋白质。已经研究了几种神经营养因子对多巴胺能神经元的保护作用。在这里，我们回顾了一些最有前途的因素，并提供了它们在临床试验中的最新状况。