Jones Philip, Simons Benjamin D
Philip Jones is at the MRC Cancer Cell Unit, Hutchison/MRC Research Centre, Cambridge, CB2 2XZ, UK.
Nat Rev Mol Cell Biol. 2008 Jan;9(1):82-8. doi: 10.1038/nrm2292.
Tracking the fate of cells in murine epidermis in vivo has revealed that a committed progenitor cell population can maintain normal adult tissue in the long term without support from a long-lived, self-renewing population of stem cells. Here, we argue that these results challenge the dogma that stem-cell proliferation is required for the cellular homeostasis of the epidermis and other adult tissues, with important implications for tissue physiology and disease.
对小鼠表皮细胞在体内的命运追踪显示，一群定向祖细胞能够在长期内维持正常的成年组织，而无需长寿的自我更新干细胞群体的支持。在此，我们认为这些结果挑战了表皮和其他成年组织细胞稳态需要干细胞增殖这一教条，对组织生理学和疾病具有重要意义。
