Liu Xiaohong, Lou Hongxiang
School of Pharmacy, Shandong University, Jinan, PR China.
Nat Prod Res. 2007 Nov;21(13):1157-64. doi: 10.1080/14786410701592356.
Nine novel monoterpene alkaloid derivatives (3(a)-(c), 4(a)-(c), 5(a)-(c)) were prepared as a reaction of genipin 2 with L-amino acid methyl hydrochlorides utilized the reaction of reductive amination. Genipin was obtained by beta-glucosidase, catalyzed hydrolysis of the iridoid glucoside geniposide 1. The chemical structures were confirmed by 1D-, 2D-NMR and MS.
以京尼平2与L-氨基酸甲基盐酸盐通过还原胺化反应制备了九种新型单萜生物碱衍生物（3(a)-(c)、4(a)-(c)、5(a)-(c)）。京尼平是通过β-葡萄糖苷酶催化环烯醚萜苷京尼平苷1水解得到的。其化学结构经一维、二维核磁共振谱和质谱确证。
