Department of Molecular Biophysics, Faculty of Biology and Environmental Protection, University of Lodz, 90-136 Lodz, Poland.
Int J Mol Sci. 2018 Nov 9;19(11):3533. doi: 10.3390/ijms19113533.
This paper describes the substances of plant and marine origin that have anticancer properties. The chemical structure of the molecules of these substances, their properties, mechanisms of action, their structure⁻activity relationships, along with their anticancer properties and their potential as chemotherapeutic drugs are discussed in this paper. This paper presents natural substances from plants, animals, and their aquatic environments. These substances include the vinca alkaloids, mistletoe plant extracts, podophyllotoxin derivatives, taxanes, camptothecin, combretastatin, and others including geniposide, colchicine, artesunate, homoharringtonine, salvicine, ellipticine, roscovitine, maytanasin, tapsigargin, and bruceantin. Compounds (psammaplin, didemnin, dolastin, ecteinascidin, and halichondrin) isolated from the marine plants and animals such as microalgae, cyanobacteria, heterotrophic bacteria, invertebrates (e.g., sponges, tunicates, and soft corals) as well as certain other substances that have been tested on cells and experimental animals and used in human chemotherapy.
本文介绍了具有抗癌特性的植物和海洋来源的物质。本文讨论了这些物质的分子的化学结构、性质、作用机制、结构-活性关系，以及它们的抗癌特性和作为化疗药物的潜力。本文介绍了来自植物、动物及其水生环境的天然物质。这些物质包括长春花生物碱、槲寄生植物提取物、鬼臼毒素衍生物、紫杉烷类、喜树碱、康普瑞汀、考布他汀等，还包括栀子苷、秋水仙碱、青蒿琥酯、高三尖杉酯碱、苦参碱、椭圆体碱、罗司卡品、美坦辛、塔斯品碱和布鲁斯汀。从海洋植物和动物（如微藻、蓝细菌、异养细菌、无脊椎动物（如海绵、被囊动物和软珊瑚））中分离出的化合物（沙麦平、迪德明、多拉司他汀、埃克替宁和海兔毒素）以及其他一些已在细胞和实验动物上进行测试并用于人类化疗的物质。
