枇杷叶倍半萜糖苷和多羟基三萜类化合物的降血糖作用

Hypoglycemic effects of sesquiterpene glycosides and polyhydroxylated triterpenoids of Eriobotrya japonica.

作者信息

De Tommasi N, De Simone F, Cirino G, Cicala C, Pizza C

机构信息

Dipartimento di Chimica delle Sostanze Naturali Università di Napoli Federico II, Italy.

出版信息

Planta Med. 1991 Oct;57(5):414-6. doi: 10.1055/s-2006-960137.

DOI:10.1055/s-2006-960137

PMID:1798792

Abstract

The effects of the constituent sesquiterpene glycosides 1-3 and polyhydroxylated triterpenoids 5-6 isolated by MeOH extraction of Eriobotrya japonica were studied in genetically diabetic mice (C57BL/KS-db/db/Ola) and normoglycemic rats. The sesquiterpene glycoside 3 and the polyhydroxylated triterpenoids 5 and 6 produced a marked inhibition of glycosuria. Furthermore, 5 and 6 were able to reduce blood glucose levels in normoglycemic rats. While there are already some data reported on hypoglycemic activity of polyhydroxylated triterpenoids, there are no previous data showing hypoglycemic activity of sesquiterpene glycosides.

摘要

通过甲醇提取枇杷叶分离得到的倍半萜糖苷1 - 3和多羟基三萜5 - 6，在遗传性糖尿病小鼠（C57BL/KS - db/db/Ola）和正常血糖大鼠中研究了它们的作用。倍半萜糖苷3以及多羟基三萜5和6对糖尿产生了显著抑制作用。此外，5和6能够降低正常血糖大鼠的血糖水平。虽然已经有一些关于多羟基三萜降血糖活性的报道，但之前没有数据表明倍半萜糖苷具有降血糖活性。