Basnet P, Kadota S, Shimizu M, Namba T
Research Institute for Wakan-Yaku (Traditional Sino-Japanes Medicines), Toyama Medical and Pharmaceutical University, Japan.
Planta Med. 1994 Dec;60(6):507-11. doi: 10.1055/s-2006-959560.
Hypoglycemic activity-guided fractionation led to the isolation of five known xanthones and two triterpenoids from the ethyl acetate soluble fraction of Swertia japonica and their identification was based on spectroscopic methods. One of the triterpenes, thysanolactone, was first isolated from this plant. Among the xanthones, bellidifolin showed a potent and dose-dependent hypoglycemic activity in STZ-induced diabetic rats both in i.p. and p.o. administration. A comparative hypoglycemic activity of the other three xanthones together with bellidifolin was also studied.
通过降血糖活性导向的分级分离，从日本獐牙菜的乙酸乙酯可溶部分中分离出5种已知的呫吨酮和2种三萜类化合物，并通过光谱方法对其进行了鉴定。其中一种三萜类化合物，thysanolactone，首次从该植物中分离得到。在呫吨酮类化合物中，bellidifolin在腹腔注射和口服给药时，对链脲佐菌素诱导的糖尿病大鼠均表现出强效且剂量依赖性的降血糖活性。还研究了其他三种呫吨酮与bellidifolin的降血糖活性比较。
