Tanaka Kazunari, Nishizono Shoko, Makino Nozomi, Tamaru Shizuka, Terai Osamu, Ikeda Ikuo
Graduate School of Human Health Science, Siebold University of Nagasaki, 1-1-1 Manabino, Nishisonogi-gun, Nagasaki 851-2195, Japan.
Biosci Biotechnol Biochem. 2008 Mar;72(3):686-93. doi: 10.1271/bbb.70411. Epub 2008 Mar 7.
The hypoglycemic effects of Eriobotrya japonica seeds were investigated in type 2 diabetic Otsuka Long-Evans Tokushima fatty (OLETF) rats and KK-A(y) mice. The rats and mice were fed on a diet containing 10% powdered Eriobotrya japonica seeds with the coat intact for 4 months. Although the blood glucose concentration in the OLETF rats fed on the control diet without Eriobotrya japonica seeds was increased with time, the concentration in the OLETF rats fed on the diet with Eriobotrya japonica seeds was consistently low throughout the experimental period and was comparable to the level in Long-Evans Tokushima Otsuka (LETO) rats which are normal non-diabetic rats. Serum insulin was significantly lower in the OLETF rats fed on the Eriobotrya japonica seed diet than in those fed on the control diet at the termination of the experimental period. Eriobotrya japonica seeds suppressed the increment of blood glucose for 4 months and also effectively improved the glucose tolerance in the KK-A(y) mice, these actions being mainly exerted by the ethanol extract of the seeds. These results suggest that Eriobotrya japonica seeds had a hypoglycemic property and the effect is attributable to the components extracted by ethanol.
在2型糖尿病大冢长- Evans德岛肥胖（OLETF）大鼠和KK - A（y）小鼠中研究了枇杷种子的降血糖作用。给大鼠和小鼠喂食含有10%完整带壳枇杷种子粉末的饲料，持续4个月。尽管未喂食枇杷种子的对照饮食的OLETF大鼠的血糖浓度随时间升高，但喂食含枇杷种子饮食的OLETF大鼠在整个实验期间血糖浓度始终较低，且与正常非糖尿病的大冢长- Evans德岛（LETO）大鼠的水平相当。在实验期结束时，喂食枇杷种子饮食的OLETF大鼠的血清胰岛素显著低于喂食对照饮食的大鼠。枇杷种子抑制血糖升高达4个月，并且还有效改善了KK - A（y）小鼠的葡萄糖耐量，这些作用主要由种子的乙醇提取物发挥。这些结果表明，枇杷种子具有降血糖特性，且该作用归因于乙醇提取的成分。
