某些三萜类糖苷的降血糖活性。

Hypoglycemic activity of some triterpenoid glycosides.

作者信息

Kako M, Miura T, Nishiyama Y, Ichimaru M, Moriyasu M, Kato A

机构信息

Suzuka University of Medical Science and Technology, Mie, Japan.

出版信息

J Nat Prod. 1997 Jun;60(6):604-5. doi: 10.1021/np9605403.

DOI:10.1021/np9605403

PMID:9214731

Abstract

Four triterpenoid glycosides isolated from the rhizomes of Polygala senega var. latifolia, senegins II-IV (1-3) and desmethoxysenegin II (4), were tested for hypoglycemic activity in normal and KK-Ay mice. Compounds 1 and 2 reduced the blood glucose of normal mice 4 h after intraperitoneal administration and also significantly lowered the glucose level of KK-Ay mice under similar conditions. Compounds 3 and 4, as well as senegose A (5), an oligosaccharide ester, were inactive when tested against normal mice.

摘要

从宽叶远志根茎中分离得到的四种三萜糖苷，远志皂苷II-IV（1-3）和去甲氧基远志皂苷II（4），在正常小鼠和KK-Ay小鼠中进行了降血糖活性测试。化合物1和2腹腔注射4小时后可降低正常小鼠的血糖水平，在类似条件下也能显著降低KK-Ay小鼠的血糖水平。化合物3和4以及一种寡糖酯远志糖A（5），在对正常小鼠进行测试时无活性。