Abd el Hafiz M A, Ramadan M A, Jung M L, Beck J P, Anton R
Pharmacognosy Department, Faculty of Pharmacy, Assiut University, Egypt.
Planta Med. 1991 Oct;57(5):437-9. doi: 10.1055/s-2006-960144.
The cytotoxic activity of five minor Amaryllidaceae alkaloids and one flavan isolated from Crinum augustum Rox and Crinum bulbispermum Milne were tested on human leukemic Molt 4 cells. Whereas the crinine-type alkaloids (6 alpha-hydroxycrinine, powelline) and the new type augustamine did not even inhibit the growth of Molt 4 cells, the lycorine-type alkaloid (pratorinine) and the crinine-type alkaloid (6 alpha-hydroxybuphanisine) showed a moderate cytotoxic activity and the flavan (4'-hydroxy-7-methoxyflavan) showed an important cytotoxic effect.
对从奥古斯丁文殊兰（Crinum augustum Rox）和多籽文殊兰（Crinum bulbispermum Milne）中分离出的5种小檗科生物碱和1种黄烷醇对人白血病Molt 4细胞的细胞毒性活性进行了测试。其中，海葱碱型生物碱（6α-羟基海葱碱、鲍威灵）和新型生物碱奥古斯他明甚至没有抑制Molt 4细胞的生长，而石蒜碱型生物碱（普拉托宁）和海葱碱型生物碱（6α-羟基布法尼辛）表现出中等的细胞毒性活性，黄烷醇（4'-羟基-7-甲氧基黄烷）表现出显著的细胞毒性作用。
