School of Pharmacy, Shenyang Pharmaceutical University, Shenyang, PR China.
Fitoterapia. 2011 Dec;82(8):1152-9. doi: 10.1016/j.fitote.2011.07.012. Epub 2011 Jul 23.
Zuojinwan, which consists of Rhizoma coptidis-Evodia rutaecarpa powder (6:1,g/g), is a traditional Chinese medicine (TCM) prescription, clinically used for the treatment of gastro-intestinal disorders. This study compared the pharmacokinetics of dehydroevodiamine and coptisine, the main active ingredients in Zuojinwan, in rats administrated with whole prescription or single herbs. Multiple blood concentration peaks were observed in the mean plasma-concentration curves. The pharmacokinetic parameters were quite different between single herbs and Zuojinwan prescription. Moreover, the mean plasma concentration of dehydroevodiamine increased and the one of coptisine decreased after combining, which was in accord with the clinical principle of TCM.
左金丸由黄连-吴茱萸粉末（6:1，g/g）组成，是一种中药方剂，临床上用于治疗胃肠功能紊乱。本研究比较了左金丸全方和单味药给药后大鼠体内脱氢吴茱萸碱和黄连碱这两种主要活性成分的药代动力学特征。平均血药浓度曲线显示出多个血药浓度峰值。单味药和左金丸全方的药代动力学参数有很大差异。此外，合并后脱氢吴茱萸碱的平均血浆浓度增加，黄连碱的浓度降低，这符合中医的临床原理。
