LmrR是乳酸乳球菌中多药ABC转运蛋白LmrCD表达的转录阻遏物。
LmrR is a transcriptional repressor of expression of the multidrug ABC transporter LmrCD in Lactococcus lactis.
作者信息
Agustiandari Herfita, Lubelski Jacek, van den Berg van Saparoea H Bart, Kuipers Oscar P, Driessen Arnold J M
机构信息
Department of Microbiology, University of Groningen, Kerklaan 30, 9751 NN, Haren, The Netherlands.
出版信息
J Bacteriol. 2008 Jan;190(2):759-63. doi: 10.1128/JB.01151-07. Epub 2007 Nov 9.
Abstract
LmrCD is an ABC-type multidrug transporter in Lactococcus lactis. LmrR encodes a putative transcriptional regulator. In a DeltalmrR strain, lmrCD is up-regulated. LmrR binds the promoter region of lmrCD and interacts with drugs that cause lmrCD up-regulation. This suggests that LmrR is a drug-dependent transcriptional regulator of lmrCD expression.
摘要
LmrCD是乳酸乳球菌中的一种ABC型多药转运蛋白。LmrR编码一种假定的转录调节因子。在ΔlmrR菌株中，lmrCD上调。LmrR结合lmrCD的启动子区域，并与导致lmrCD上调的药物相互作用。这表明LmrR是lmrCD表达的药物依赖性转录调节因子。
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