Hospital of the National Institute of Radiological Sciences, National Institutes for Quantum and Radiological Sciences and Technology, Chiba, Japan.
Department of Radiology, Hyogo Ion Beam Medical Center, Tatsuno, Japan.
Cancer Med. 2019 Sep;8(12):5482-5491. doi: 10.1002/cam4.2408. Epub 2019 Aug 1.
The aim of this study was to evaluate the efficacy and safety of carbon-ion radiation therapy for nonsquamous cell carcinomas of the oral cavity in a multicenter study.
Retrospective analysis of the clinicopathological features and outcomes of 76 patients with oral nonsquamous cell carcinomas with N0-1 M0 status and were treated with carbon-ion radiation therapy at four institutions in Japan between November 2003 and December 2014 was performed.
Salivary gland carcinoma, mucosal melanoma, and three other carcinomas were found in 46, 27, and 3 patients, respectively. T1-3, T4a, and T4b disease was diagnosed in 27, 18, and 31 patients, respectively. Median follow-up period was 31.1 months (range, 3-118 months). Three-year local control, progression-free survival, and overall survival of all patients were 86.8%, 63.1%, and 78.4%, respectively. Multivariate analysis showed T classification (T4) to be a significant independent poor prognostic factor for local control. Acute grade 3 mucositis was observed in 38 patients. Grades 3 and 4 late morbidities were observed in 9 and 4 patients, respectively. No grade 5 late toxicity was observed.
Oral nonsquamous cell carcinomas could be treated effectively, with acceptable toxicity, by carbon-ion radiation therapy.
本研究旨在评估碳离子放疗治疗口腔非鳞状细胞癌的疗效和安全性。
回顾性分析了 2003 年 11 月至 2014 年 12 月期间，4 家日本机构对 76 例 N0-1 M0 期口腔非鳞状细胞癌患者进行碳离子放疗的临床病理特征和疗效。
46 例为涎腺癌，27 例为黏膜黑色素瘤，3 例为其他 3 种癌，T1-3、T4a 和 T4b 期分别诊断为 27、18 和 31 例。中位随访时间为 31.1 个月（3-118 个月）。所有患者的 3 年局部控制率、无进展生存率和总生存率分别为 86.8%、63.1%和 78.4%。多因素分析显示 T 分期（T4）是局部控制的独立不良预后因素。38 例患者出现急性 3 级黏膜炎，9 例和 4 例患者分别出现 3 级和 4 级迟发性并发症，无 5 级迟发性毒性。
口腔非鳞状细胞癌可以通过碳离子放疗有效治疗，毒性可接受。
