Agnati Luigi F, Fuxe Kjell G, Goncharova Larisa B, Tarakanov Alexander O
Department of Biomedical Sciences, University of Modena and Reggio Emilia, Italy.
Brain Res Rev. 2008 Aug;58(2):400-14. doi: 10.1016/j.brainresrev.2007.10.002. Epub 2007 Oct 17.
Receptor assemblies seem to play a key role in the integration and modulation of molecular signals of cell-cell communications. This may be confirmed by recent discoveries of the immunological synapse and cytokine networks which can be also treated within a sort of meta-system-neuroimmune molecular network. On the examples of receptor superfamilies expressed both in the neural and immune cells, our review paper aims to show some implications of receptor-receptor interactions for basal ganglia functions in health and disease.
受体组装似乎在细胞间通讯分子信号的整合与调节中发挥关键作用。这一点可能已被免疫突触和细胞因子网络的最新发现所证实,这些也可在一种元系统——神经免疫分子网络中进行探讨。以在神经细胞和免疫细胞中均有表达的受体超家族为例,我们的综述文章旨在展示受体 - 受体相互作用对健康和疾病状态下基底神经节功能的一些影响。