基底神经节中的自主起搏器：到底谁需要兴奋性突触呢？

Autonomous pacemakers in the basal ganglia: who needs excitatory synapses anyway?

作者信息

Surmeier D James, Mercer Jeff N, Chan C Savio

机构信息

Department of Physiology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois 60611, USA.

出版信息

Curr Opin Neurobiol. 2005 Jun;15(3):312-8. doi: 10.1016/j.conb.2005.05.007.

DOI:10.1016/j.conb.2005.05.007

PMID:15916893

Abstract

Autonomous pacemakers are crucial elements in many neural circuits. This is particularly true for the basal ganglia. This richly interconnected group of nuclei is rife with both fast- and slow-spiking pacemakers. Our understanding of the ionic mechanisms underlying pacemaking in these neurons is rapidly evolving, yielding new insights into the normal functioning of this network and how it goes awry in pathological states such as Parkinson's disease.

摘要

自主起搏器是许多神经回路中的关键元件。基底神经节尤其如此。这个高度相互连接的核团群中充斥着快速和慢速发放的起搏器。我们对这些神经元中起搏活动背后离子机制的理解正在迅速发展，这为该网络的正常功能以及在帕金森病等病理状态下其功能如何出现异常提供了新的见解。